Oak Ridge, Tennessee, USA
The Biology and Soft Matter Division of the Neutron Sciences Directorate of ORNL runs world-class scientific neutron crystallography and neutron scattering programs. The Biology and Soft Matter Division, in partnership with collaborators at the University of California-San Diego and the University of Utah, has an immediate opening for a Postdoctoral Research Associate to participate in an NIH-funded collaborative translational project directed to developing a new generation of accelerated oxime reactivators of nerve agent and pesticide organophosphate(OP)-inhibited human acetylcholinesterase (hAChE). The successful candidate will investigate the structure and function of hAChE, and identify structurally imposed limiting factors in oxime reactivation of the enzyme inhibited by OP. The postdoctoral researcher will join the research team that uses a multidisciplinary approach combining biochemistry, X-ray and neutron crystallography, small-angle scattering (SAXS, TR-SAXS, SANS), neutron spectroscopy and computational modeling (QM/MM/MD) to understand how slow molecular motions, protonation and ionization states in the mechanism of oxime reactivation of OP-inhibited hAChE influence and in effect limit antidotes’ efficacy.
The Neutron Sciences Directorate (NScD) at Oak Ridge National Laboratory (ORNL) operates the High Flux Isotope Reactor (HFIR), the United States’ highest flux reactor based neutron source, and the Spallation Neutron Source (SNS), the world’s most intense pulsed accelerator based neutron source. Together these facilities operate 27 instruments for neutron scattering research, each year carrying out in excess of 1,000 experiments in the physical, chemical, materials, biological and medical sciences for more than 3,000 visiting scientists. HFIR also provides unique facilities for isotope production and neutron irradiation. To learn more about Neutron Sciences at ORNL go to: http://neutrons.ornl.gov.
A Ph.D. in biochemistry, biophysics or a related discipline completed within the last 5 years is required. Research experience with biochemical methods for production, purification and crystallization of proteins, and X-ray crystallography is required. Candidates should be self-motivated, have good interpersonal, communication and presentation skills and a demonstrated ability to interact effectively with staff at all levels. The ability to work as a member of a multi-disciplinary team is a critical asset.
Employment is contingent upon the results of a pre-employment physical exam and drug screen which must be administered and cleared before employment can begin.
Experience with either small-angle scattering (SAXS or SANS) and the analysis of scattering data, or neutron macromolecular crystallography is desirable. Knowledge of mechanistic biochemistry is highly desirable. The aspiration to learn is highly desirable.
Please provide a list of publications when applying for this position. A minimum of 2 letters of reference are required and can be uploaded to your profile or emailed directly to firstname.lastname@example.org. Please include the title of the position in the subject line.
Applicants must have received their PhD within five years of this application and must complete all degree requirements before starting their appointment.
This position will remain open for a minimum of 5 days after which it will close when a qualified candidate is identified and/or hired.
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