[Neutron] Benno Schoenborn wins Bau Neutron Award his pioneering research at the Los Alamos Neutron Scattering Center (LANSCE).
Llobet Megias, Anna
allobet at lanl.gov
Thu Aug 13 00:19:54 CEST 2015
Benno Schoenborn wins Bau Neutron Award his pioneering research at the Los Alamos Neutron Scattering Center (LANSCE).
The American Crystallographic Association (ACA) has selected retired Laboratory Senior Fellow Benno Schoenborn, formerly of Bioenergy and Biome Sciences (B-11), to receive the 2016 Bau Neutron Diffraction Award. The Award recognizes exceptional research achievement in neutron diffraction. Schoenborn is honored for his pioneering research in macromolecular neutron crystallography and the design and development of the neutron crystallography beamline (Protein Crystallography Station, PCS) at the Los Alamos Neutron Scattering Center (LANSCE).
Schoenborn has been called the “father of neutron crystallography.” Neutron crystallography uses neutron diffraction to elucidate protein structures. When a beam of neutrons hits a crystallized protein, the neutrons are scattered by the crystal and their diffraction pattern is recorded. This approach reveals information about the location of hydrogen atoms, which provides insight for enzyme mechanisms, hydrogen bonding and water structure in macromolecules.
Schoenborn received a doctorate in physics from the University of New South Wales, Australia. Before coming to Los Alamos, he worked at Brookhaven National Laboratory, where he conducted innovative work in macromolecular neutron crystallography, beginning with the very first neutron structure of myoglobin in 1969. He performed his first demonstration of this technique at a time when few scientists believed that it was even possible. Schoenborn persevered and proved that neutron diffraction of macromolecular crystals was not only possible but that the information gleaned was unique and extremely useful. He received an Ernest Orlando Lawrence Award in 1980.
Upon arrival at LANL in 1993, Schoenborn began work on designing and building the first neutron protein crystallography beamline (the Protein Crystallography Station) at a spallation neutron source at LANSCE. Schoenborn, with colleagues Eric Pitcher, Phil Ferguson, and Paul Langan, designed every component of the Protein Crystallography Station to maximize the neutron intensity and reduce background scattering. This achievement enabled scientists to collect excellent data in 15 to 30 days of beam time using small protein crystals. The big payoff was that the larger proteins, for which large crystals are nearly impossible to grow, became amenable to neutron crystallography.
When it was completed in 2002, the Protein Crystallography Station was the first macromolecular crystallography beamline at a spallation neutron source, until the completion of the iBIX station in Japan in 2008. The Protein Crystallography Station remained the only macromolecular crystallography station in North America until the commissioning of instruments at Oak Ridge National Laboratory starting in 2010. The Protein Crystallography Station has been used as an example for this type of instrument in construction of similar beamlines at the Australian Nuclear Science and Technology Organisation and Oak Ridge National Laboratory. Over the last 14 years, research at the Laboratory’s Protein Crystallography Station has revealed a number of unexpected and critical data on enzyme mechanisms and highlighted the unique characteristics and chemistry of enzyme active sites. The data have proved to be critical for drug design and protein engineering.
About the ACA
The American Crystallographic Association, Inc. is a nonprofit, scientific organization of over 2,200 members in more than 60 countries. Founded in 1949, the Association promotes interactions among scientists who study the structure of matter at atomic (or near atomic) resolution. These interactions advance experimental and computational aspects of crystallography and diffraction. Understanding the nature of the forces that both control and result from the molecular and atomic arrangements in matter will provide insight into chemical interactions in nature and could lead to treatments for disease.
The Bau Neutron Diffraction Award is given in memory of Professor Robert Bau, University of Southern California (1969-2008) and President of the American Crystallographic Association (2006). Professor Bau made major contributions to the development of the technique of single-crystal neutron diffraction and to its applications in chemical and biomacromolecular crystallography. The award consists of an honorarium and travel reimbursement to accept the award and deliver the award lecture at an ACA annual meeting. Schoenborn is the second recipient of this triennial award.
Dr. Anna Llobet
Deputy Group Leader (acting)
P-23 Neutron Science and Technology
Los Alamos National Laboratory
Los Alamos, NM 87545, USA
Phone: +1 505 665-1367
Cell: +1 505 695-4799
Fax: +1 505 665-4121
Email: allobet at lanl.gov<mailto:allobet at lanl.gov>
Export license: TSPA, Correspondence--
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