[Neutron] ORNL: Beamline Postdoctoral Research Associate / NB50546297

McCormick, B. Logan mccormickbl at ornl.gov
Mon Feb 15 22:17:55 CET 2016

ORNL Publications
External Publication

Job Posting Title
Beamline Postdoctoral Research Associate / NB50546297

Posted Date

End Posting Date

The Neutron Sciences Directorate (NScD) at Oak Ridge National Laboratory (ORNL) operates the High Flux Isotope Reactor
(HFIR), the United States' highest flux reactor based neutron source, and the Spallation Neutron Source (SNS), the world's
most intense pulsed accelerator based neutron source. Together these facilities operate 30 instruments for neutron scattering
research, each year carrying out in excess of 1,000 experiments in the physical, chemical, materials, biological and medical
sciences for more than 3,000 visiting scientists. To learn more about Neutron Sciences at ORNL go to:

The Macromolecular Neutron Diffractometer (MaNDi) located at the SNS is a single crystal diffractometer optimized for high
signal to noise data collection with applications in computational chemistry, molecular magnets, and protein crystallography.
A macromolecular neutron diffractometer is also under consideration as an instrument at the proposed SNS Second Target
Station (STS). The successful candidate will conduct scientific research, engage in beamline operations at the MaNDi
instrument and be an active participant in developing the conceptual design of a new neutron protein crystallography
instrument proposed for the STS. Training will be given in various aspects of neutron protein crystallography (NPC) including
sample preparation, beamline operation, data collection, data processing and refinement.

Major Duties/Responsibilities
Responsible to participate in operations of the MaNDi beam line and provide beam line support to a limited number of users.
* The successful candidate will be part of the Energy and the Environment group in the Biology and Soft Matters Division at
ORNL and will be expected to take part in all group activities, which include seminars and weekly meetings.
* The successful candidate will also be part of a growing team of instrument scientists and specialists developing conceptual
designs for STS instruments and will contribute to development of the design of a new NPC instrument for STS.
* Conducts and publishes scientific research using the MaNDi instrument.

Qualifications Required
Applicants must hold a Ph.D. in structural biology, or related discipline, and have strong expertise in protein expression and
purification and X-ray crystallography. Candidates must be self-motivated, have good interpersonal, communication and
presentational skills.

Qualifications Desired:
Previous experience with time-of-flight neutron crystallography is desirable as well as experience gained in conducting
experiments at national user facilities. Skills gained in the development of scientific apparatus that include computational
modeling and designs are desired. Some knowledge of neutron data collection on MaNDi and the Mantid project for single
crystal time of flight data reduction are desirable. Experience with the expression and purification of membrane or
membrane-associated proteins is highly desirable. Experience of ligand binding studies using biophysical methods such as
SPR or ITC would be desirable.

Work Directions and Interfaces
Reports to the MaNDi lead instrument scientist. Will interface with the MaNDi instrument team, users of the MaNDi
instrument, and with members of the STS instrument design team.

This position will remain open for a minimum of 5 days after which it will close when a qualified candidate is identified and/or

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If you have trouble applying for a position, please email ORNLRecruiting at ornl.gov<mailto:ORNLRecruiting at ornl.gov>.

Notice: If the position requires a Security Clearance, reviews and tests for the absence of any illegal drug as defined in 10
CFR 707.4 will be conducted by the employer and a background investigation by the Federal government may be required
to obtain an access authorization prior to employment and subsequent reinvestigations may be required.
If the position is covered by the Counterintelligence Evaluation Program regulations at 10 CFR 709, a counterintelligence
evaluation may include a counterintelligence-scope polygraph examination.

ORNL is an equal opportunity employer. All qualified applicants, including individuals with disabilities and protected
veterans, are encouraged to apply. UT-Battelle is an E-Verify Employer.
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