<html><head><meta http-equiv="Content-Type" content="text/html; charset=utf-8"></head><body style="word-wrap: break-word; -webkit-nbsp-mode: space; line-break: after-white-space;" class=""><div class="">Postdoc at the Materials Physics Center in San Sebastian (Spain)</div><div class=""><br class=""></div><div class="">PROFILE: Scattering Experiments on crowded macromolecular solutions. We are looking for highly-motivated experimentalists with a PhD in condensed or soft matter physics or in material science. Previous experience with scattering techniques, in particular light scattering, will be highly valuated.<br class=""><br class=""><br class="">Details about this call can be found here: <span style="font-size: 14px;" class=""><span style="color: rgb(192, 0, 0); font-weight: bold;" class="">http://</span><span style="color: rgb(192, 0, 0); font-weight: bold;" class=""><a href="http://cfm.ehu.es" class="">cfm.ehu.es</a></span><span style="color: rgb(192, 0, 0); font-weight: bold;" class="">/</span><span style="color: rgb(192, 0, 0); font-weight: bold;" class="">about-cfm</span><span style="color: rgb(192, 0, 0); font-weight: bold;" class="">/</span><span style="color: rgb(192, 0, 0); font-weight: bold;" class="">job-offers</span><span style="color: rgb(192, 0, 0); font-weight: bold;" class="">/</span></span></div>
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<!--EndFragment--><div class=""><br class=""></div><div class="">For further information please contact: Arantxa Arbe (<a href="mailto:a.arbe@ehu.es" class="">a.arbe@ehu.eus</a>)</div><br class=""><br class="">DESCRIPTION OF THE PROJECT:<br class=""><br class="">
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<!--StartFragment--><p class="MsoNormal"><span lang="EN-US" class="">CROWDING EFFECTS ON THE BEHAVIOR OF
MACROMOLECULAR NANO-OBJECTS<o:p class=""></o:p></span></p><p class="MsoNormal"><span lang="EN-US" class=""> </span></p><p class="MsoNormal"><span lang="EN-US" class="">The general
framework of this project is to contribute to the understanding of crowding
effects on the structure and dynamics of macromolecules of diverse types. We
are currently running a project focused on single-chain nano-particles (SCNPs)
–soft nano-objects obtained by intramolecular cross-linking of individual
macromolecules. In dilute conditions, SCNPs have been found to adopt sparse
morphologies, reminiscent of those presented by intrinsically disordered
proteins (IDPs) under the same dilute conditions. This similarity motivates the
use of synthetic SCNPs as mimicking nano-objects for IDP to investigate
structural as well as dynamical aspects as functions of different variables. The
proposed project aims to characterize the influence of increasing the
concentration of the macromolecular environment of SCNPs and IDPs. In this way,
we try to extract universal features due to steric effects of the behavior of
biomacromolecules in the crowded conditions typical for cellular environments. The
study will be based on the application of scattering techniques, in particular
neutron scattering on deuterium-labeled samples, as well as small angle X-ray
scattering (SAXS), static and dynamic light scattering (SLS and DLS) available
in our labs. Experience of the candidate in light scattering will be
particularly appreciated. </span><o:p class=""></o:p></p>
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